Open AccessYersinia pseudotuberculosis Anti-Inflammatory Components Reduce Trinitrobenzene Sulfonic Acid-Induced Colitis in the Mouse
Author(s) -
Michaël Marceau,
Laurent Dubuquoy,
Christel Caucheteux-Rousseaux,
Benoît Foligné,
Pierre Desreumaux,
Michel Simonet
Publication year - 2004
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.72.4.2438-2441.2004
Subject(s) - yersinia pseudotuberculosis , colitis , microbiology and biotechnology , virulence , tumor necrosis factor alpha , biology , sulfonic acid , mutant , immunology , chemistry , biochemistry , gene , polymer chemistry
Rectal instillation of trinitrobenzene sulfonic acid (TNBS) induces acute colitis in the mouse. We tested the efficacy of Yersinia pseudotuberculosis anti-inflammatory components in preventing TNBS-triggered colitis. Animals were orally inoculated with virulence-attenuated Yersinia cells (a phoP mutant) prior to TNBS administration. Under these experimental conditions, colonic lesions and tumor necrosis factor alpha mRNA levels were significantly reduced.