Open AccessIdentification of srv , a PrfA-Like Regulator of Group A Streptococcus That Influences Virulence
Author(s) -
Sean D. Reid,
Alison G. Montgomery,
James M. Musser
Publication year - 2004
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.72.3.1799-1803.2004
Subject(s) - virulence , streptococcus pyogenes , biology , regulator , listeria monocytogenes , microbiology and biotechnology , gene , streptococcus , bacteria , genetics , staphylococcus aureus
We have identified a Crp/Fnr-like transcriptional regulator of Streptococcus pyogenes that when inactivated attenuates virulence. The gene, named srv for streptococcal regulator of virulence, encodes a 240-amino-acid protein with 53% amino acid similarity to PrfA, a transcriptional activator of virulence in Listeria monocytogenes.