Open AccessHeat Shock Protein 60 Is the Major Antigen Which Stimulates Delayed-Type Hypersensitivity Reaction in the Macaque Model ofChlamydia trachomatisSalpingitis
Author(s) -
Anne Lichtenwalner,
Dorothy L. Patton,
Wesley C. Van Voorhis,
Yvonne T. Cosgrove Sweeney,
ChoChou Kuo
Publication year - 2004
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.72.2.1159-1161.2004
Subject(s) - chlamydia trachomatis , antigen , biology , heat shock protein , chlamydiaceae , microbiology and biotechnology , chlamydiales , immunology , virology , chlamydia , serotype , lymphogranuloma venereum , gene , biochemistry
Chlamydial delayed-type hypersensitivity antigens were analyzed by using the subcutaneous salpingeal autotransplant model of Macaca nemestrina infected with Chlamydia trachomatis serovar E. Heat shock protein 60 was the only antigen shown to induce delayed-type hypersensitivity among other antigens tested, including UV-inactivated organisms, recombinant major outer membrane protein, purified outer membrane proteins, and heat shock protein 10.