Open AccessEvaluation of the Role of Constitutive Isocitrate Lyase Activity inYersinia pestisInfection of the Flea Vector and Mammalian Host
Author(s) -
Florent Sebbane,
Clayton O. Jarrett,
Jan Linkenhoker,
B. Joseph Hinnebusch
Publication year - 2004
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.72.12.7334-7337.2004
Subject(s) - yersinia pestis , biology , isocitrate lyase , host (biology) , flea , microbiology and biotechnology , vector (molecular biology) , yersinia , virology , bacteria , virulence , recombinant dna , ecology , enzyme , genetics , gene , biochemistry , glyoxylate cycle
Yersinia pestis, unlike the closely related Yersinia pseudotuberculosis, constitutively produces isocitrate lyase (ICL). Here we show that the Y. pestis aceA homologue encodes ICL and is required for growth on acetate but not for flea infection or virulence in mice. Thus, deregulation of the glyoxylate pathway does not underlie the recent adaptation of Y. pestis to arthropod-borne transmission.