Open AccessStable T-Cell Population Expressing an Effector Cell Surface Phenotype in the Lungs of Mice Chronically Infected with Mycobacterium tuberculosis
Author(s) -
Ana Paula Junqueira-Kipnis,
Joanne Turner,
Mercedes Gonzalez-Juarrero,
Oliver C. Turner,
Ian M. Orme
Publication year - 2004
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.72.1.570-575.2004
Subject(s) - biology , mycobacterium tuberculosis , effector , phenotype , cell , cd8 , interferon gamma , tuberculosis , t cell , immunology , population , virology , microbiology and biotechnology , immune system , pathology , genetics , gene , medicine , environmental health
Analysis of T-cell subsets accumulating in the lungs of C57BL/6 mice chronically infected with Mycobacterium tuberculosis revealed that both CD4 and CD8 T-cell populations expressed a cell surface phenotype consistent with that of effector T cells and that a significant proportion of these cells were in the process of secreting gamma interferon.