Open AccessSignaling via Toll-Like Receptor 5 Can Initiate Inflammatory Mediator Production by Murine Osteoblasts
Author(s) -
Denise R. Madrazo,
Susanne Tranguch,
Ian Marriott
Publication year - 2003
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.71.9.5418-5421.2003
Subject(s) - tlr5 , flagellin , proinflammatory cytokine , biology , microbiology and biotechnology , toll like receptor , mediator , downregulation and upregulation , cytokine , receptor , signal transduction , inflammation , immunology , tlr4 , tlr2 , innate immune system , gene , biochemistry
Murine osteoblasts express Toll-like receptor 5 (TLR5), and this expression is upregulated following exposure to bacteria or to the TLR5 agonist, flagellin. Importantly, flagellin activates transcriptional regulators and elicits proinflammatory cytokine production, suggesting TLR5 functionality. TLR5 may represent an important mechanism underlying the recognition of bacterial pathogens by osteoblasts during bone infections.