Open AccessNicotinamide Ribosyl Uptake Mutants in Haemophilus influenzae
Author(s) -
Mark Herbert,
Elizabeta Sauer,
Graeme Smethurst,
Anita Kraiß,
Anna-Karina Hilpert,
Joachim Reidl
Publication year - 2003
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.71.9.5398-5401.2003
Subject(s) - haemophilus influenzae , biology , mutant , microbiology and biotechnology , nicotinamide , in vivo , in vitro , transporter , gene , biochemistry , genetics , antibiotics , enzyme
The gene for the nicotinamide riboside (NR) transporter (pnuC) was identified in Haemophilus influenzae. A pnuC mutant had only residual NR uptake and could survive in vitro with high concentrations of NR, but could not survive in vivo. PnuC may represent a target for the development of inhibitors for preventing H. influenzae disease.