Open AccessVγ9Vδ2 T-Cell Anergy and Complementarity-Determining Region 3-Specific Depletion during Paroxysm of Nonendemic Malaria Infection
Author(s) -
Federico Martini,
Maria Grazia Paglia,
Carla Montesano,
Patrick Enders,
Marco Gentile,
C. David Pauza,
Cristiana Gioia,
Vittorio Colizzi,
Pasquale Narciso,
Leopoldo Paolo Pucillo,
Fabrizio Poccia
Publication year - 2003
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.71.5.2945-2949.2003
Subject(s) - biology , malaria , immunology , t cell , virology , immune system
V gamma 9V delta 2 T lymphocytes strongly respond to phosphoantigens from Plasmodium parasites. Thus, we analyzed the changes in V gamma 9V delta 2 T-cell function and repertoire during the paroxysm phase of nonendemic malaria infection. During malaria paroxysm, V gamma 9V delta 2 T cells were early activated but rapidly became anergic and finally loose J gamma 1.2 V gamma 9 complementarity-determining region 3 transcripts.