Open AccessBidirectional Concentration-Dependent Effects of Tumor Necrosis Factor Alpha in Shigella dysenteriae -Related Seizures
Author(s) -
Yael Yuhas,
Abraham Weizman,
Shai Ashkenazi
Publication year - 2003
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.71.4.2288-2291.2003
Subject(s) - shigella dysenteriae , tumor necrosis factor alpha , shigella , biology , immunology , microbiology and biotechnology , pharmacology , bacteria , salmonella , biochemistry , escherichia coli , genetics , gene
We have previously demonstrated that pretreatment of mice with Shigella dysenteriae sonicate enhanced their susceptibility to pentylenetetrazole-induced seizures and that tumor necrosis factor alpha (TNF-alpha) was proconvulsive in this respect. The present study shows that TNF-alpha, at high concentrations, may also exert a suppressive effect on Shigella-mediated seizures. This implies that high levels of TNF-alpha may play a protective role in neurologic complications of S. dysenteriae infection.