Open AccessEnhanced Phagocytosis ofCandidaSpecies Mediated by Opsonization with a Recombinant Human Antibody Single-Chain Variable Fragment
Author(s) -
Melanie Wellington,
Joseph M. Bliss,
Constantine G. Haidaris
Publication year - 2003
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.71.12.7228-7231.2003
Subject(s) - antibody opsonization , opsonin , phagocytosis , biology , recombinant dna , antibody , microbiology and biotechnology , complement system , immunology , biochemistry , gene
Specific antibody opsonization significantly enhances the level of phagocytosis of Candida in the absence of complement. Furthermore, we have described a system using a recombinant human antibody single-chain variable fragment that allows a comparative study of phagocytosis of multiple Candida species opsonized via a common antigen.