Open AccessMycobacterium aviumsubsp. paratuberculosisInfection Causes Suppression of RANTES, Monocyte Chemoattractant Protein 1, and Tumor Necrosis Factor Alpha Expression in Peripheral Blood of Experimentally Infected Cattle
Author(s) -
Joram Buza,
Yoshihide Mori,
Abusaleh Mahfuzul Bari,
Hirokazu Hikono Aodon-geril,
Sachiyo Hirayama,
Yujing Shu,
Eiichi Momotani
Publication year - 2003
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.71.12.7223-7227.2003
Subject(s) - biology , paratuberculosis , tumor necrosis factor alpha , monocyte , subclinical infection , immunology , chemokine , peripheral blood mononuclear cell , microbiology and biotechnology , antigen , immune system , mycobacterium , virology , bacteria , biochemistry , genetics , in vitro
Blood from cattle with subclinical Mycobacterium avium subsp. paratuberculosis infection was stimulated with M. avium subsp. paratuberculosis antigens, and expression of interleukin-1beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), RANTES, monocyte chemoattractant protein 1 (MCP-1), and IL-8 was measured. Expression of TNF-alpha, RANTES, and MCP-1 was lower in infected than in uninfected cattle. The reduced response may weaken protective immunity and perpetuate infection.