Open AccessADirofilaria immitisPolyprotein Up-Regulates Nitric Oxide Production
Author(s) -
Hiroyuki Tezuka,
Shoichi Imai,
Setsuko Tsukidate,
Kazuo Fujita
Publication year - 2002
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.70.9.5283-5286.2002
Subject(s) - nitric oxide , biology , lipopolysaccharide , dirofilaria immitis , microbiology and biotechnology , recombinant dna , macrophage , immunology , in vitro , biochemistry , helminths , endocrinology , gene
We investigated the effect of recombinant Dirofilaria immitis polyprotein (rDiAg) on nitric oxide (NO) production by peritoneal macrophages. rDiAg induced NO production by macrophages from wild-type and lipopolysaccharide-hyporesponsive C3H/HeJ, but not CD40(-/-), mice. These results suggest that CD40 is involved in rDiAg-driven NO production by murine macrophages.