Open Accesscag+Helicobacter pyloriInduces Homotypic Aggregation of Macrophage-Like Cells by Up-Regulation and Recruitment of Intracellular Adhesion Molecule 1 to the Cell Surface
Author(s) -
Stefan Moese,
Matthias Selbach,
Thomas F. Meyer,
Steffen Backert
Publication year - 2002
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.70.8.4687-4691.2002
Subject(s) - intracellular , biology , macrophage , microbiology and biotechnology , cell adhesion , cell , cell adhesion molecule , adhesion , intercellular adhesion molecule 1 , intercellular adhesion molecule , helicobacter pylori , cell signaling , cell–cell interaction , signal transduction , in vitro , biochemistry , chemistry , genetics , organic chemistry
Infection with cag+ but not cag-negative Helicobacter pylori leads to the formation of large homotypic aggregates of macrophage-like cells. Intracellular adhesion molecule 1 is up-regulated and recruited to the cell surface of infected cells and mediates the aggregation via lymphocyte function-associated molecule 1. This signaling may regulate cell-cell interactions and inflammatory responses.