Open AccessReevaluation of the Role of HWP1 in Systemic Candidiasis by Use of Candida albicans Strains with Selectable Marker URA3 Targeted to the ENO1 Locus
Author(s) -
Paula Sundstrom,
Jim E. Cutler,
Janet F. Staab
Publication year - 2002
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.70.6.3281-3283.2002
Subject(s) - biology , systemic candidiasis , candida albicans , ura3 , microbiology and biotechnology , mutagenesis , invasive candidiasis , selectable marker , corpus albicans , genetics , gene , plasmid , antifungal , mutation , fluconazole
Previous evaluation of HWP1 in systemic candidiasis in CBA/J mice was done with Candida albicans strains with differing genetic locations of URA3 as a result of Ura-blaster mutagenesis. In this study, the presence of HWP1 and the location of URA3 contributed to the severity of murine systemic candidiasis in BALB/c mice.