Open AccessDendritic Cells Can Initiate Protective Immune Responses against Malaria
Author(s) -
Oscar Bruña–Romero,
Ana Rodrı́guez
Publication year - 2001
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.69.8.5173-5176.2001
Subject(s) - plasmodium yoelii , immune system , biology , immunology , malaria , antigen presentation , antigen , immunization , cross presentation , dendritic cell , cd8 , plasmodium (life cycle) , virology , plasmodium falciparum , t cell , parasite hosting , parasitemia , world wide web , computer science
An understanding of the antigen presentation mechanisms that mediate induction of protective immune responses against malaria is essential for the development of successful immunization approaches. Here we show that dendritic cells presenting Plasmodium yoelii sporozoite antigens are able to activate specific CD4(+) and CD8(+) T cells and initiate protective immune responses against malaria in mice.