Open AccessNormal IncA Expression and Fusogenicity of Inclusions in Chlamydia trachomatis Isolates with the incA I47T Mutation
Author(s) -
Yvonne Pannekoek,
Arie van der Ende,
Paul P. Eijk,
J. van Marle,
Moniek A. de Witte,
Jacobus M. Ossewaarde,
Adriaan J. C. van den Brule,
Servaas A. Morré,
J. Dankert
Publication year - 2001
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.69.7.4654-4656.2001
Subject(s) - biology , chlamydia trachomatis , mutation , phenotype , chlamydiaceae , chlamydiales , chlamydia , genetics , sequence (biology) , gene , microbiology and biotechnology , virology
To investigate the correlation between the incA I47T mutation in Chlamydia trachomatis and the nonfusogenic phenotype, the incA genes of 25 isolates were sequenced. Four major sequence types were identified. Seven isolates (28%) had the I47T mutation. Isolates representing the four sequence types expressed IncA in the membrane of one large single inclusion. In conclusion, the incA I47T mutation is not associated with the nonfusogenic phenotype.