Open AccessLocal and Systemic Immune Responses to Rectal Administration of Recombinant Cholera Toxin B Subunit in Humans
Author(s) -
Marianne Jertborn,
Inger Nordström,
Anders Kilander,
Cécil Czerkinsky,
Jan Holmgren
Publication year - 2001
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.69.6.4125-4128.2001
Subject(s) - cholera toxin , biology , antitoxin , immune system , antibody , cholera vaccine , cholera , immunology , recombinant dna , isotype , immunoglobulin a , toxin , humoral immunity , immunoglobulin g , microbiology and biotechnology , vibrio cholerae , monoclonal antibody , bacteria , biochemistry , genetics , gene
The induction of immune responses to rectally administered recombinant cholera toxin B subunit (CTB) in humans was studied. Three immunizations induced high levels of CTB-specific antibody-secreting cells, particular of the immunoglobulin A isotype, in both rectum and peripheral blood. Antitoxin antibody responses in rectal secretions and serum were also found.