Open AccessShear Stress Prevents Fibronectin Binding Protein-Mediated Staphylococcus aureus Adhesion to Resting Endothelial Cells
Author(s) -
K. V. nkata Reddy,
Julia M. Ross
Publication year - 2001
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.69.5.3472-3475.2001
Subject(s) - staphylococcus aureus , fibronectin , biology , microbiology and biotechnology , adhesion , cell adhesion , staphylococcal infections , bacteria , cell , biochemistry , extracellular matrix , materials science , genetics , composite material
Fibronectin binding proteins (FnBP) on the surface of Staphylococcus aureus have previously been shown to mediate adherence of the organism to resting endothelial cells in static adhesion assays. However, in this study using well-defined flow assays, we demonstrate that physiologic levels of shear stress prevent FnBP-mediated adhesion of S. aureus 8325-4 to resting endothelial cells. This result suggests that mechanical forces present in vivo may influence the ability of staphylococci to bind endothelial cell surfaces.