Open AccessPassive Immunization with Melanin-Binding Monoclonal Antibodies Prolongs Survival of Mice with Lethal Cryptococcus neoformans Infection
Author(s) -
Ángel L. Rosas,
Joshua D. Nosanchuk,
Arturo Casadevall
Publication year - 2001
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.69.5.3410-3412.2001
Subject(s) - cryptococcus neoformans , monoclonal antibody , biology , melanin , immunization , antibody , microbiology and biotechnology , cryptococcosis , cryptococcus , immunology , in vitro , monoclonal , virology , biochemistry , genetics
Passive immunization with monoclonal antibodies (MAbs) to melanin prolonged the survival of and reduced the fungal burden in Cryptococcus neoformans-infected mice in comparison to controls. MAbs to melanin reduced the growth rate of in vitro-melanized C. neoformans cells, suggesting a new mechanism of antibody-mediated protection.