Open AccessIntracellular Crystal Formation as a Mechanism of Cytotoxicity in Murine PulmonaryCryptococcus neoformansInfection
Author(s) -
Marta Feldmesser,
Yvonne Kress,
Arturo Casadevall
Publication year - 2001
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.69.4.2723-2727.2001
Subject(s) - cryptococcus neoformans , biology , microbiology and biotechnology , intracellular , cytoplasm , cryptococcus , cryptococcosis , yeast , pathogenesis , cytotoxicity , intracellular parasite , immunology , biochemistry , in vitro
Rod-like crystalline structures formed during eosinophilic Cryptococcus neoformans pneumonia in C57BL/6 mice. Crystals were found associated with yeast cells and free in host cell cytoplasm. The crystals apparently formed because of the interaction of a host protein with the cryptococcal polysaccharide. Crystal formation likely contributes to pathogenesis by causing cellular damage.