Open AccessSera from Adult Patients with Cystic Fibrosis Contain Antibodies to Pseudomonas aeruginosa Type III Apparatus
Author(s) -
Joel Moss,
Mary Ehrmantraut,
Bruce D. Banwart,
Dara W. Frank,
Joseph T. Barbieri
Publication year - 2001
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.69.2.1185-1188.2001
Subject(s) - pseudomonas aeruginosa , cystic fibrosis , antibody , biology , immune system , microbiology and biotechnology , chromosomal translocation , immunology , virology , bacteria , biochemistry , genetics , gene
Expression of type III proteins of Pseudomonas aeruginosa in patients with cystic fibrosis (CF) was investigated by measuring the immune response against components of the type III pathway. Twenty-three of the 33 sera contained antibodies against PcrV, a protein involved in translocation of type III cytotoxins into eukaryotic cells, and 11 of 33 had antibodies against ExoS, while most CF sera contained antibodies against PopB and PopD, components of the type III apparatus. These data indicate that P. aeruginosa commonly expresses components of the type III translocation apparatus in adult CF patients.