Open AccessEffect of SpeB and EndoS from Streptococcus pyogenes on Human Immunoglobulins
Author(s) -
Mattias Collin,
Arne Olsén
Publication year - 2001
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.69.11.7187-7189.2001
Subject(s) - streptococcus pyogenes , immunoglobulin d , glycan , antibody , biology , immunoglobulin g , microbiology and biotechnology , immunoglobulin a , immunoglobulin e , immunoglobulin m , protease , streptococcus , enzyme , immunology , glycoprotein , biochemistry , b cell , bacteria , genetics , staphylococcus aureus
Streptococcus pyogenes secretes a specific immunoglobulin G (IgG)-protease, SpeB, as well as the IgG glycan-hydrolyzing enzyme EndoS. Here we show that SpeB also degrades IgA, IgM, IgD, and IgE. We also show that EndoS only hydrolyzes the glycan moiety on native but not denatured IgG. Thus, SpeB has a broad immunoglobulin-degrading activity, while EndoS is highly specific for IgG.