Open AccessHigh-Level Expression of NRAMP1 in Peripheral Blood Cells and Tuberculous Granulomas fromMycobacterium bovis-Infected Bovines
Author(s) -
Ciro Estrada-Chávez,
Ana Laura PereiraSuárez,
Marco Antonio Meraz,
C. Arriaga,
Alejandro GarcíaCarrancá,
Cristina Sánchez-Rodriguez,
Raúl Mancilla
Publication year - 2001
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.69.11.7165-7168.2001
Subject(s) - mycobacterium bovis , biology , peripheral blood , tuberculosis , microbiology and biotechnology , mycobacterium , mycobacterium tuberculosis , virology , immunology , pathology , bacteria , medicine , genetics
By Western blotting, we demonstrate high-level expression of NRAMP1 proteins in peripheral blood cells and granulomas of Mycobacterium bovis-infected bovines. Immunohistochemistry of granulomatous lesions showed heavily labeled epithelioid macrophages and Langhans cells. These data suggest that M. bovis infection enhances NRAMP1 expression and that active tuberculosis can occur despite this response.