Open AccessMouse Cytokine Profiles Associated with Brucella abortus RB51 Vaccination or B. abortus 2308 Infection
Author(s) -
Paolo Pasquali,
Rosanna Adone,
Louis C. Gasbarre,
Claudia Pistoia,
F. Ciuchini
Publication year - 2001
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.69.10.6541-6544.2001
Subject(s) - brucella abortus , biology , brucellaceae , microbiology and biotechnology , brucella , brucellosis , cytokine , vaccination , interferon gamma , virology , lipopolysaccharide , bacteria , immunology , brucella melitensis , genetics
This study indicated that mice immunized with Brucella abortus RB51 bacteria and subsequently challenged with B. abortus 2308 were protected from reinfection. After vaccination, both Th1 and Th2 cytokine patterns were observed. Of those, the early production of gamma interferon seems to have the prominent role in inducing an immunologically based protection.