Open AccessImmunity againstHelicobacter pylori: Significance of Interleukin-4 Receptor α Chain Status and Gender of Infected Mice
Author(s) -
Toni Aebischer,
Stephanie Laforsch,
Robert Hurwitz,
Frank Brombacher,
Thomas F. Meyer
Publication year - 2001
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.69.1.556-558.2001
Subject(s) - biology , helicobacter pylori , salmonella enterica , immunity , microbiology and biotechnology , cholera toxin , salmonella , immunology , interleukin , humoral immunity , immune system , virology , cytokine , bacteria , genetics
Vaccination of interleukin-4 (IL-4) receptor alpha (IL-4Ralpha) chain-deficient BALB/c mice with Helicobacter pylori urease and cholera toxin or with urease-expressing, live attenuated Salmonella enterica serovar Typhimurium cells revealed that protection against H. pylori infection is independent of IL-4- or IL-13-mediated signals. A comparison of male and female mice suggests a sexual dimorphism in the extent of bacterial colonization that is particularly evident in the absence of the IL-4Ralpha chain.