Open AccessInterleukin-10 Has Different Effects on Proliferation ofListeria monocytogenesin Livers and Spleens of Mice
Author(s) -
Janneke N. Samsom,
A Annema,
M. F. Geertsma,
Jan A. M. Langermans,
P. H. P. Groeneveld,
Emile de Heer,
R. van Furth
Publication year - 2000
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.68.8.4666-4672.2000
Subject(s) - listeria monocytogenes , spleen , immune system , biology , listeria infection , listeria , immunology , microbiology and biotechnology , interferon , bacteria , interleukin , interferon gamma , cytokine , genetics
The aim of this study was to investigate the effect of interleukin-10 (IL-10) on the course ofListeria monocytogenes infection in naive and immune mice. Treatment with IL-10 during the course of a primary infection significantly decreased the number of bacteria in the spleen and did not affect the number in the liver. During a secondary infection in immune mice treated with IL-10, the number of bacteria was significantly lower in the spleen but significantly higher in the liver in comparison to mock-treated immune mice. IL-10 treatment during a primaryListeria infection decreased the concentration of gamma interferon (IFN-γ) in plasma and the toxoplasmastatic activity of macrophages, whereas it increased the percentage of mildly CD3-positive T cells in the spleen. During a secondary infection, the concentration of IFN-γ in plasma was decreased on day 1 but remained unaffected during later days of infection. From these results, we conclude that IL-10 has different effects on the proliferation ofL. monocytogenes in the spleen and liver during primary and secondaryListeria infections.