Open AccessLatency-Associated Peptide of Transforming Growth Factor β Enhances Mycobacteriocidal Immunity in the Lung duringMycobacterium bovisBCG Infection in C57BL/6 Mice
Author(s) -
Katalin A. Wilkinson,
Thomas Martin,
Scott M. Reba,
Htin Aung,
Raymond W. Redline,
W. Henry Boom,
Zahra Toossi,
Scott A. Fulton
Publication year - 2000
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.68.11.6505-6508.2000
Subject(s) - biology , mycobacterium bovis , immunity , transforming growth factor , interferon gamma , immune system , microbiology and biotechnology , immunology , in vivo , antigen , lung , mycobacterium tuberculosis , tuberculosis , medicine , pathology
Latency-associated peptide of transforming growth factor β (TGF-β) (LAP) was used to determine whether in vivo modulation of TGF-β bioactivity enhanced pulmonary immunity toMycobacterium bovis BCG infection in C57BL/6 mice. LAP decreased BCG growth in the lung and enhanced antigen-specific T-cell proliferation and gamma interferon mRNA expression. Thus, susceptibility of the lung to primary BCG infection may be partially mediated by the immunosuppressive effects of TGF-β.