Open AccessThe Putative Glycosyltransferase-Encoding Gene cylJ and the Group B Streptococcus (GBS)-Specific Gene cylK Modulate Hemolysin Production and Virulence of GBS
Author(s) -
Marie-Pierre Forquin,
Asmaa Tazi,
Manuel Rosa-Fraile,
Claire Poyart,
Patrick Trieu-Cuot,
Shaynoor Dramsi
Publication year - 2007
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.01565-06
Subject(s) - biology , virulence , cytolysin , hemolysin , microbiology and biotechnology , gene , mutant , streptococcus agalactiae , transposon mutagenesis , streptococcus , glycosyltransferase , transposable element , genetics , streptococcaceae , mutagenesis , bacteria
Group B streptococcus (GBS) expresses a hemolysin/cytolysin that plays an important role in pathogenesis. Using theHimar1 transposon mutagenesis system, a hypohemolytic mutant carrying an interruptedcylJ gene was characterized.cylJ , encoding a putative glycosyltransferase, andcylK , whose product is unknown, are both required for the full hemolytic/cytolytic activity, pigment formation, and virulence of GBS.