Open AccessSurface Proteins and Exotoxins Are Required for the Pathogenesis of Staphylococcus aureus Pneumonia
Author(s) -
Juliane Bubeck Wardenburg,
Ravi J. Patel,
Olaf Schneewind
Publication year - 2007
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.01313-06
Subject(s) - staphylococcus aureus , pneumonia , microbiology and biotechnology , pathogenesis , biology , staphylococcal infections , immunology , virulence , bacteria , medicine , biochemistry , genetics , gene
A model ofStaphylococcus aureus -induced pneumonia in adult, immunocompetent C57BL/6J mice is described. This model closely mimics the clinical and pathological features of pneumonia in human patients. Using this system, we defined a role forS. aureus strain Newman surface proteins and secreted exotoxins in pneumonia-related mortality.