Open AccessYersinia pseudotuberculosis Adhesins Regulate Tissue-Specific Colonization and Immune Cell Localization in a Mouse Model of Systemic Infection
Author(s) -
Krischan J. Hudson,
Amy H. Bouton
Publication year - 2006
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.00718-06
Subject(s) - yersinia pseudotuberculosis , bacterial adhesin , biology , colonization , spleen , yersinia , microbiology and biotechnology , immune system , immunology , bacteria , escherichia coli , virulence , biochemistry , genetics , gene
Yersinia pseudotuberculosis mutants deficient for the adhesins invasin and/or YadA were injected intravenously into BALB/c mice. Invasin expression inhibited colonization of the liver and spleen. YadA decreased liver colonization but promoted growth within the lung. The persistence of leukocytes within liver microabscesses correlated with enhanced colonization and lack of adhesin expression.