Open AccessThe Salmochelin Siderophore Receptor IroN Contributes to Invasion of Urothelial Cells by Extraintestinal Pathogenic Escherichia coli In Vitro
Author(s) -
Friederike Feldmann,
Liisa Johanna Sorsa,
Kirsten Hildinger,
Sören Schubert
Publication year - 2007
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.00656-06
Subject(s) - siderophore , biology , microbiology and biotechnology , escherichia coli , in vitro , internalization , receptor , enterobacteriaceae , bacteria , biochemistry , gene , genetics
Extraintestinal pathogenicEscherichia coli (ExPEC) strains possess several siderophore-dependent iron uptake systems. In this study we demonstrated that the salmochelin siderophore receptor IroN is involved in the invasion of urothelial cells by ExPEC in vitro. Thus, IroN may play a dual role in the establishment of urinary tract infections, displaying an iron uptake receptor as well as an internalization factor.