Open AccessPPE37 Is Essential for Mycobacterium tuberculosis Heme-Iron Acquisition (HIA), and a Defective PPE37 in Mycobacterium bovis BCG Prevents HIA
Author(s) -
Michael V. Tullius,
Susava,
Marcus A. Horwitz
Publication year - 2018
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.00540-18
Subject(s) - siderophore , mycobacterium tuberculosis , mycobacterium bovis , heme , biology , microbiology and biotechnology , tuberculosis , ferrous , iron deficiency , mycobacterium , bacteria , biochemistry , chemistry , anemia , enzyme , medicine , genetics , pathology , organic chemistry
Mycobacterium tuberculosis , one of the world’s leading causes of death, must acquire nutrients, such as iron, from the host to multiply and cause disease. Iron is an essential metal andM. tuberculosis possesses two different systems to acquire iron from its environment: siderophore-mediated iron acquisition (SMIA) and heme-iron acquisition (HIA), involving uptake and degradation of heme to release ferrous iron.
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