Open AccessRole of Supramolecule ErpY-Like Lipoprotein of Leptospira in Thrombin-Catalyzed Fibrin Clot Inhibition and Binding to Complement Factors H and I, and Its Diagnostic Potential
Author(s) -
Karukriti Kaushik Ghosh,
Aman Prakash,
Anusua Dhara,
Md. Saddam Hussain,
Purnima Shrivastav,
Pankaj Kumar,
V. Balamurugan,
Manish Kumar
Publication year - 2019
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.00536-19
Subject(s) - fibrin , thrombin , leptospira , biology , thrombin generation , complement system , biochemistry , lipoprotein , microbiology and biotechnology , biophysics , immunology , cholesterol , platelet , antibody , serotype
Leptospirosis is one of the most widespread zoonoses caused by pathogenicLeptospira spp. In this study, we report that the LIC11966/ErpY-like lipoprotein is a surface-exposed outer membrane protein exclusively present in pathogenic species ofLeptospira . The recombinant ErpY (rErpY)-like protein is recognized by the immunoglobulins of confirmed leptospirosis sera of diverse hosts (human, bovine, and canine), suggesting the expression of the native leptospiral surface protein during infection.
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