Heterogeneity of a Campylobacter jejuni Protein That Is Secreted through the Flagellar Filament | Zendy

Frédéric Poly | Zendy; Cheryl P. Ewing | Zendy; Scarlett Goon | Zendy; Thomas E. Hickey | Zendy; David Rockabrand | Zendy; Gary Majam | Zendy; Lanfong Lee | Zendy; Julie Phan | Zendy; Nicholas J. Savarino | Zendy; Patricia Guerry | Zendy

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Heterogeneity of a Campylobacter jejuni Protein That Is Secreted through the Flagellar Filament

Author(s) -

Frédéric Poly,

Cheryl P. Ewing,

Scarlett Goon,

Thomas E. Hickey,

David Rockabrand,

Gary Majam,

Lanfong Lee,

Julie Phan,

Nicholas J. Savarino,

Patricia Guerry

Publication year - 2007

Publication title -

infection and immunity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.508

H-Index - 220

eISSN - 1070-6313

pISSN - 0019-9567

DOI - 10.1128/iai.00159-07

Subject(s) - campylobacter jejuni , biology , virulence , microbiology and biotechnology , virulence factor , flagellum , secretion , recombinant dna , campylobacter , bacteria , gene , secretory protein , genetics , biochemistry

Cj0859c, or FspA, is a small, acidic protein of Campylobacter jejuni that is expressed by a sigma(28) promoter. Analysis of the fspA gene in 41 isolates of C. jejuni revealed two overall variants of the predicted protein, FspA1 and FspA2. Secretion of FspA occurs in broth-grown bacteria and requires a minimum flagellar structure. The addition of recombinant FspA2, but not FspA1, to INT407 cells in vitro resulted in a rapid induction of apoptosis. These data define a novel C. jejuni virulence factor, and the observed heterogeneity among fspA alleles suggests alternate virulence potential among different strains.

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