The Neurospora crassa DCC-1 Protein, a Putative Histidine Kinase, Is Required for Normal Sexual and Asexual Development and Carotenogenesis | Zendy

Carlos BarbaOstria | Zendy; Fernando Lledı́as | Zendy; Dimitris Georgellis | Zendy

Open Access

The Neurospora crassa DCC-1 Protein, a Putative Histidine Kinase, Is Required for Normal Sexual and Asexual Development and Carotenogenesis

Author(s) -

Carlos BarbaOstria,

Fernando Lledı́as,

Dimitris Georgellis

Publication year - 2011

Publication title -

eukaryotic cell

Language(s) - English

Resource type - Journals

eISSN - 1535-9778

pISSN - 1535-9786

DOI - 10.1128/ec.05223-11

Subject(s) - neurospora crassa , conidiation , biology , histidine kinase , response regulator , two component regulatory system , neurospora , archaea , protein kinase a , microbiology and biotechnology , fungal protein , histidine , kinase , mutant , crassa , biochemistry , gene , context (archaeology) , signal transduction , genetics , amino acid , paleontology

Two-component signaling pathways based on phosphoryl group transfer between histidine kinase and response regulator proteins regulate environmental responses in bacteria, archaea, plants, slime molds, and fungi. Here we characterize a mutant form of DCC-1, a putative histidine kinase encoded by the NCU00939 gene of the filamentous fungus Neurospora crassa. We show that this protein participates in the regulation of processes such as conidiation, perithecial development, and, to a certain degree, carotenogenesis. Furthermore, DCC-1 is suggested to exert its effect by promoting cyclic AMP production, thereby placing this protein within the context of a signaling pathway.

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