Multiple Roles of Ypd1 Phosphotransfer Protein in Viability, Stress Response, and Virulence Factor Regulation in Cryptococcus neoformans | Zendy

Jang-Won Lee | Zendy; Young-Joon Ko | Zendy; Seoyoung Kim | Zendy; YongSun Bahn | Zendy

Open Access

Multiple Roles of Ypd1 Phosphotransfer Protein in Viability, Stress Response, and Virulence Factor Regulation in Cryptococcus neoformans

Author(s) -

Jang-Won Lee,

Young-Joon Ko,

Seoyoung Kim,

YongSun Bahn

Publication year - 2011

Publication title -

eukaryotic cell

Language(s) - English

Resource type - Journals

eISSN - 1535-9778

pISSN - 1535-9786

DOI - 10.1128/ec.05124-11

Subject(s) - cryptococcus neoformans , biology , virulence , virulence factor , mapk/erk pathway , protein kinase a , cryptococcus , function (biology) , microbiology and biotechnology , signal transduction , kinase , genetics , gene

Ypd1 is a key phosphorelay protein that controls eukaryotic two-component systems, but its function in Cryptococcus neoformans is not known. Here, we report that Ypd1 is required for the viability of C. neoformans via the Hog1 mitogen-activated protein kinase (MAPK) pathway but plays multiple cellular roles in both a Hog1-dependent and -independent manner.

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