RNA Interference in Fungi: Pathways, Functions, and Applications | Zendy

Yunkun Dang | Zendy; Qiuying Yang | Zendy; Zhihong Xue | Zendy; Yi Liu | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

RNA Interference in Fungi: Pathways, Functions, and Applications

Author(s) -

Yunkun Dang,

Qiuying Yang,

Zhihong Xue,

Yi Liu

Publication year - 2011

Publication title -

eukaryotic cell

Language(s) - English

Resource type - Journals

eISSN - 1535-9778

pISSN - 1535-9786

DOI - 10.1128/ec.05109-11

Subject(s) - rna interference , biology , dicer , argonaute , rasirna , rna silencing , genetics , rna , trans acting sirna , computational biology , microbiology and biotechnology , rna induced silencing complex , gene

Small RNA molecules of about 20 to 30 nucleotides function in gene regulation and genomic defense via conserved eukaryotic RNA interference (RNAi)-related pathways. The RNAi machinery consists of three core components: Dicer, Argonaute, and RNA-dependent RNA polymerase. In fungi, the RNAi-related pathways have three major functions: genomic defense, heterochromatin formation, and gene regulation. Studies of Schizosaccharomyces pombe and Neurospora, and other fungi have uncovered surprisingly diverse small RNA biogenesis pathways, suggesting that fungi utilize RNAi-related pathways in various cellular processes to adapt to different environmental conditions. These studies also provided important insights into how RNAi functions in eukaryotic systems in general. In this review, we will discuss our current understanding of the fungal RNAi-related pathways and their functions, with a focus on filamentous fungi. We will also discuss how RNAi can be used as a tool in fungal research.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research