Drosophila melanogaster Thor and Response to Candida albicans Infection | Zendy

Anastasia Levitin | Zendy; Anne Marcil | Zendy; Gritta Tettweiler | Zendy; Marie-Josée Laforest | Zendy; Ursula Oberholzer | Zendy; AnneMarie Alarco | Zendy; David Y. Thomas | Zendy; Paul Lasko | Zendy; Malcolm Whiteway | Zendy

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Drosophila melanogaster Thor and Response to Candida albicans Infection

Author(s) -

Anastasia Levitin,

Anne Marcil,

Gritta Tettweiler,

Marie-Josée Laforest,

Ursula Oberholzer,

AnneMarie Alarco,

David Y. Thomas,

Paul Lasko,

Malcolm Whiteway

Publication year - 2007

Publication title -

eukaryotic cell

Language(s) - English

Resource type - Journals

eISSN - 1535-9778

pISSN - 1535-9786

DOI - 10.1128/ec.00346-06

Subject(s) - biology , drosophila melanogaster , candida albicans , melanogaster , corpus albicans , innate immune system , mutant , gene , microbiology and biotechnology , regulator , genetics , immune system

We used Drosophila melanogaster macrophage-like Schneider 2 (S2) cells as a model to study cell-mediated innate immunity against infection by the opportunistic fungal pathogen Candida albicans. Transcriptional profiling of S2 cells coincubated with C. albicans cells revealed up-regulation of several genes. One of the most highly up-regulated genes during this interaction is the D. melanogaster translational regulator 4E-BP encoded by the Thor gene. Analysis of Drosophila 4E-BP(null) mutant survival upon infection with C. albicans showed that 4E-BP plays an important role in host defense, suggesting a role for translational control in the D. melanogaster response to C. albicans infection.

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