Regulatable Ras Activity Is Critical for Proper Establishment and Maintenance of Polarity in Aspergillus fumigatus | Zendy

Jarrod R. Fortwendel | Zendy; Praveen R. Juvvadi | Zendy; Luise E. Rogg | Zendy; William J. Steinbach | Zendy

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Regulatable Ras Activity Is Critical for Proper Establishment and Maintenance of Polarity in Aspergillus fumigatus

Author(s) -

Jarrod R. Fortwendel,

Praveen R. Juvvadi,

Luise E. Rogg,

William J. Steinbach

Publication year - 2011

Publication title -

eukaryotic cell

Language(s) - English

Resource type - Journals

eISSN - 1535-9778

pISSN - 1535-9786

DOI - 10.1128/ec.00315-10

Subject(s) - aspergillus fumigatus , biology , polarity (international relations) , microbiology and biotechnology , computational biology , aspergillus nidulans , fungal protein , genetics , saccharomyces cerevisiae , gene , cell , mutant

Here we show that expression of a constitutively activated RasA allele, as the sole source of Ras activity, revealed novel Ras-induced phenotypes, including excessive vacuolar expansion and spontaneous lysis of hyphal compartments. These findings highlight the requirement for balanced Ras activity in the establishment and maintenance of polarized growth in filamentous fungi.

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