Open AccessAntigenic Variation in Plasmodium falciparum : Gene Organization and Regulation of the var Multigene Family
Author(s) -
Sue Kyes,
Susan M. Kraemer,
Joseph D. Smith
Publication year - 2007
Publication title -
eukaryotic cell
Language(s) - English
Resource type - Journals
eISSN - 1535-9778
pISSN - 1535-9786
DOI - 10.1128/ec.00173-07
Subject(s) - biology , plasmodium falciparum , antigenic variation , genetics , gene , gene family , antigen , regulation of gene expression , virology , gene expression , malaria , immunology
Plasmodium falciparum imposes an enormous burden upon the developing world, with 300 to 500 million cases and 1 to 2 million deaths per year ([94][1]). Despite extensive research efforts, development of parasite drug resistance is a growing problem, and an effective vaccine is still lacking.
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