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Plasmodium falciparum imposes an enormous burden upon the developing world, with 300 to 500 million cases and 1 to 2 million deaths per year ([94][1]). Despite extensive research efforts, development of parasite drug resistance is a growing problem, and an effective vaccine is still lacking.

Antigenic Variation in Plasmodium falciparum : Gene Organization and Regulation of the var Multigene Family