Articles of Significant Interest Selected from This Issue by the Editors

Regulation of protein expression in kinetoplastids is predominantly posttranscriptional. Accordingly, trypanosomes possess extended families of eIF4E-like and eIF4G-like translation-initiation factors. Through examination of the Trypanosoma brucei mRNA capbinding homolog TbEIF4E6, Freire et al. (p. 896 –908) describe a stable tripartite complex that also contains TbEIF4G5 and a protein with nucleotide triphosphate hydrolase and guanylyltransferase domains similar to those found in mRNA capping enzymes. RNAi knockdown of TbEIF4E6 results in a detached-flagellum phenotype and reduction in social motility behavior. A specific subset of transcripts may be controlled by the tripartite complex.