Open AccessFoxA2 Involvement in Suppression of Protein C, an Outcome Predictor in Experimental Sepsis
Author(s) -
David T. Berg,
Bruce Gerlitz,
Ganesh R. Sharma,
Mark A. Richardson,
Eddie J. Stephens,
Renee L. Grubbs,
Kimberly Holmes,
Kelly A. Fynboe,
David Montani,
Martin S. Cramer,
Steven D. Engle,
Joseph A. Jakubowski,
Josef G. Heuer,
Brian W. Grinnell
Publication year - 2006
Publication title -
clinical and vaccine immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.649
H-Index - 77
eISSN - 1556-6811
pISSN - 1556-679X
DOI - 10.1128/cvi.13.3.426-432.2006
Subject(s) - foxa2 , sepsis , transcription factor , biology , messenger rna , cofactor , medicine , endocrinology , cancer research , immunology , biochemistry , gene , enzyme
Low levels of protein C (PC) predict outcome as early as 10 h after insult in a rat polymicrobial sepsis model and were associated with suppression of PC mRNA, upstream transcription factor FoxA2, and cofactor hepatocyte nuclear factor 6 (HNF6). Small interfering RNA suppression of FoxA2 in isolated hepatocytes demonstrated regulation of both its cofactor HNF6 and PC. Our data suggest that reduced FoxA2 may be important in the suppression of PC and resulting poor outcome in sepsis.