Mice with Pulmonary Tuberculosis Treated with Mycobacterium vaccae Develop Strikingly Enhanced Recall Gamma Interferon Responses to M. vaccae Cell Wall Skeleton | Zendy

Elisabeth Rodríguez-Güell | Zendy; Gemma Agustí | Zendy; Mercè Corominas | Zendy; PereJoan Cardona | Zendy; Marina Luquin | Zendy; Esther Julián | Zendy

Open Access

Mice with Pulmonary Tuberculosis Treated with Mycobacterium vaccae Develop Strikingly Enhanced Recall Gamma Interferon Responses to M. vaccae Cell Wall Skeleton

Author(s) -

Elisabeth Rodríguez-Güell,

Gemma Agustí,

Mercè Corominas,

PereJoan Cardona,

Marina Luquin,

Esther Julián

Publication year - 2008

Publication title -

clinical and vaccine immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.649

H-Index - 77

eISSN - 1556-6811

pISSN - 1556-679X

DOI - 10.1128/cvi.00477-07

Subject(s) - mycobacterium tuberculosis , tuberculosis , splenocyte , interferon gamma , immunology , mycobacterium , interferon , microbiology and biotechnology , gamma interferon , medicine , biology , cytokine , immune system , pathology

Whole heat-killed Mycobacterium vaccae is used as an immunotherapeutic agent in tuberculosis (TB), but the compound(s) that triggers its immunostimulatory ability is not known. Here, we show that among different subcellular fractions, the cell wall skeleton induced a prominent expression of gamma interferon in splenocytes from both non-TB and TB M. vaccae-treated mice.

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