A Heterologous MF59-Adjuvanted H5N1 Prepandemic Influenza Booster Vaccine Induces a Robust, Cross-Reactive Immune Response in Adults and the Elderly | Zendy

Elena Fragapane | Zendy; Roberto Gasparini | Zendy; Francesco Schioppa | Zendy; Franco LaghiPasini | Zendy; Emanuele Montomoli | Zendy; Angelika Banzhoff | Zendy

Open Access

A Heterologous MF59-Adjuvanted H5N1 Prepandemic Influenza Booster Vaccine Induces a Robust, Cross-Reactive Immune Response in Adults and the Elderly

Author(s) -

Elena Fragapane,

Roberto Gasparini,

Francesco Schioppa,

Franco LaghiPasini,

Emanuele Montomoli,

Angelika Banzhoff

Publication year - 2010

Publication title -

clinical and vaccine immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.649

H-Index - 77

eISSN - 1556-6811

pISSN - 1556-679X

DOI - 10.1128/cvi.00461-09

Subject(s) - immunogenicity , heterologous , booster (rocketry) , vaccination , immune system , immunology , medicine , influenza vaccine , booster dose , virology , hemagglutinin (influenza) , immunization , biology , antibody , gene , genetics , physics , astronomy

Immunogenicity and safety of a booster dose of an MF59-adjuvanted H5N1 vaccine containing 7.5 μg A/turkey/Turkey/1/2005-like (clade 2.2) H5N1 hemagglutinin, given approximately 18 months after primary vaccination with a heterologous strain, were evaluated. The booster vaccine was well tolerated and induced a robust, cross-reactive immune response.

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