Comparison of Four Assays for the Detection of Cryptococcal Antigen | Zendy

M. J. Binnicker | Zendy; Deborah J. Jespersen | Zendy; Jean E. Bestrom | Zendy; Leonard O. Rollins | Zendy

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Comparison of Four Assays for the Detection of Cryptococcal Antigen

Author(s) -

M. J. Binnicker,

Deborah J. Jespersen,

Jean E. Bestrom,

Leonard O. Rollins

Publication year - 2012

Publication title -

clinical and vaccine immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.649

H-Index - 77

eISSN - 1556-6811

pISSN - 1556-679X

DOI - 10.1128/cvi.00446-12

Subject(s) - latex fixation test , immunoassay , cerebrospinal fluid , antigen , immunology , microbiology and biotechnology , chromatography , medicine , chemistry , biology , antibody , pathology

We compared the performance of four assays for the detection of cryptococcal antigen in serum samples (n = 634) and cerebrospinal fluid (CSF) samples (n = 51). Compared to latex agglutination, the sensitivity and specificity of the Premier enzyme immunoassay (EIA), Alpha CrAg EIA, and CrAg lateral flow assay (LFA) were 55.6 and 100%, 100 and 99.7%, and 100 and 99.8%, respectively, from serum samples. There was 100% agreement among the four tests for CSF samples, with 18 samples testing positive by each of the assays.

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