Open AccessIdentification of and Human Serum Reactogenicity to Neutralizing Epitopes within the Central Unglycosylated Region of the Respiratory Syncytial Virus Attachment Protein
Author(s) -
Yoshihiko Murata,
Paula M. Lightfoote,
Ann R. Falsey,
Edward E. Walsh
Publication year - 2010
Publication title -
clinical and vaccine immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.649
H-Index - 77
eISSN - 1556-6811
pISSN - 1556-679X
DOI - 10.1128/cvi.00432-09
Subject(s) - virology , epitope , virus , reactogenicity , respiratory system , antibody , neutralizing antibody , biology , immunology , immunization , anatomy
We identified two overlapping neutralizing epitopes within residues 151 to 172 of the central unglycosylated region of the respiratory syncytial virus (RSV) attachment protein. In approximately 40% of hospitalized and outpatient adults infected with RSV subtype A, these contiguous residues are the target of > or =4-fold increases in IgG response between acute- and convalescent-phase sera.
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