HLA Class II Haplotypes Distinctly Associated with Vaso-Occlusion in Children with Sickle Cell Disease | Zendy

Najat Mahdi | Zendy; Khadija AlOla | Zendy; Abeer M. AlSubaie | Zendy; Muhallab E. Ali | Zendy; Zaid Alirhayim | Zendy; Abdul-Qader Al-Irhayim | Zendy; Wassim Y. Almawi | Zendy

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HLA Class II Haplotypes Distinctly Associated with Vaso-Occlusion in Children with Sickle Cell Disease

Author(s) -

Najat Mahdi,

Khadija AlOla,

Abeer M. AlSubaie,

Muhallab E. Ali,

Zaid Alirhayim,

Abdul-Qader Al-Irhayim,

Wassim Y. Almawi

Publication year - 2008

Publication title -

clinical and vaccine immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.649

H-Index - 77

eISSN - 1556-6811

pISSN - 1556-679X

DOI - 10.1128/cvi.00425-07

Subject(s) - haplotype , human leukocyte antigen , allele , genetics , sickle cell anemia , disease , immunology , cell , biology , medicine , gene , antigen

We investigated the association of HLA class II alleles and haplotypes with sickle cell anemia vaso-occlusive crisis (VOC). DRB1*100101 was positively associated, while DRB1*140101, DRB1*150101, and DQB1*060101 were negatively associated, with VOC. Both susceptible (DRB1*100101-DQB1*050101) and protective (DRB1*110101-DQB1*030101 and DRB1*150101-DQB1*060101) haplotypes were identified, indicating that HLA class II haplotypes influence VOC risk.

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