Evaluation of Seven Tests for Diagnosis of Human Brucellosis in an Area Where the Disease Is Endemic | Zendy

M. C. Gómez | Zendy; J. Aizpurua Nieto | Zendy; Carmen Rosa | Zendy; Paloma Geijo | Zendy; M. Ángeles Escribano | Zendy; Amparo Muñoz | Zendy; Clara López | Zendy

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Evaluation of Seven Tests for Diagnosis of Human Brucellosis in an Area Where the Disease Is Endemic

Author(s) -

M. C. Gómez,

J. Aizpurua Nieto,

Carmen Rosa,

Paloma Geijo,

M. Ángeles Escribano,

Amparo Muñoz,

Clara López

Publication year - 2008

Publication title -

clinical and vaccine immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.649

H-Index - 77

eISSN - 1556-6811

pISSN - 1556-679X

DOI - 10.1128/cvi.00424-07

Subject(s) - brucellosis , direct agglutination test , serology , medicine , coombs test , antibody , immunology , immunoglobulin m , agglutination (biology) , immunoglobulin g , virology

The results of seven serologic tests for diagnosis of human brucellosis were evaluated. The titrated Rose Bengal test, microagglutination test, microtiter-adapted Coombs test, and immunocapture-agglutination test (Brucellacapt) were positive for all sera from patients with acute brucellosis. The immunoglobulin G (IgG), IgM, and IgA commercial enzyme immunoassays (ELISAs) failed to show specific antibodies in 3 patients, 10 patients, and 1 patient, respectively. The sensitivity of ELISA is not higher than that of conventional tests.

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