Performance Characteristics of Microparticle Enzyme and Chemiluminescence Immunoassays for Measurement of Anti-HBc Immunoglobulin M in Sera of Patients with HBeAg-Negative Chronic Hepatitis B Virus Infection | Zendy

Emilia Hadziyannis | Zendy; Emanuel K. Manesis | Zendy; Dimitrios Vassilopoulos | Zendy; Αναστασία Γεωργίου | Zendy; Athanasios J. Archimandritis | Zendy

Open Access

Performance Characteristics of Microparticle Enzyme and Chemiluminescence Immunoassays for Measurement of Anti-HBc Immunoglobulin M in Sera of Patients with HBeAg-Negative Chronic Hepatitis B Virus Infection

Author(s) -

Emilia Hadziyannis,

Emanuel K. Manesis,

Dimitrios Vassilopoulos,

Αναστασία Γεωργίου,

Athanasios J. Archimandritis

Publication year - 2007

Publication title -

clinical and vaccine immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.649

H-Index - 77

eISSN - 1556-6811

pISSN - 1556-679X

DOI - 10.1128/cvi.00414-07

Subject(s) - antibody , chemiluminescence , virology , virus , immunology , hbeag , immunoglobulin g , medicine , hepatitis b virus , chronic hepatitis , chemistry , hbsag , chromatography

The IMx, AxSym, and Architect immunoglobulin M anti-HBc assay systems for detecting hepatitis B virus e antigen-negative chronic hepatitis B virus infection were compared. Despite good intra- and interassay coefficients of variation, significantly different values and low correlation (overestimation by AxSym and underestimation by Architect) were observed. Association and cutoff values for distinguishing patients with viral replication should be established for all methods.

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