Reduced Expression of Toll-Like Receptor 2 on Peripheral Monocytes in Patients with Chronic Hepatitis B | Zendy

Stephen M. Riordan | Zendy; Narelle Skinner | Zendy; Jelica Kurtovic | Zendy; Stephen Locarnini | Zendy; Kumar Visvanathan | Zendy

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Reduced Expression of Toll-Like Receptor 2 on Peripheral Monocytes in Patients with Chronic Hepatitis B

Author(s) -

Stephen M. Riordan,

Narelle Skinner,

Jelica Kurtovic,

Stephen Locarnini,

Kumar Visvanathan

Publication year - 2006

Publication title -

clinical and vaccine immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.649

H-Index - 77

eISSN - 1556-6811

pISSN - 1556-679X

DOI - 10.1128/cvi.00396-05

Subject(s) - immunology , toll like receptor , hepatitis b virus , innate immune system , virology , immunity , chronic hepatitis , monocyte , peripheral , virus , hepatitis b , receptor , antigen , medicine , biology , immune system

Persistent infection with hepatitis B virus (HBV) likely depends on viral inhibition of host defenses. We report that chronic hepatitis B e antigen-positive HBV infection is associated with a significant reduction in peripheral blood monocyte expression of Toll-like receptor 2, a key component of innate immunity, thereby providing a mechanism by which wild-type HBV may establish persistent infection.

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